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HL Paper 1

What is a universal characteristic of the genetic code?

A. There are more than 64 different anticodons.

B. There are more nucleotides than codons.

C. There are more codons than amino acids.

D. There are two or more amino acids for each codon.




In a copy of Louis Pasteur’s famous experiment, broth was put into flasks as shown in the diagrams.

What results would be expected with no spontaneous generation of life?

A.  Decomposition of broth by microbes occurred only in Flask W.

B.  Decomposition of broth by microbes occurred only in Flasks W and X.

C.  Decomposition of broth by microbes occurred only in Flasks W, X and Y.

D.  Decomposition of broth by microbes occurred only in Flasks W, X and Z.




What is evidence for the endosymbiotic theory?

A. RNA can catalyse metabolic reactions.

B. Meteorites contain organic molecules.

C. Amino acids can be synthesized from inorganic compounds.

D. Mitochondria possess their own DNA.




Which plasma membrane is the least fluid at high temperatures?




The first iron ore deposits in rocks appeared about 1.8 billion years ago. What took place to make this occur?

A. Some prokaryotic organisms began to absorb carbon dioxide from seawater.

B. Some eukaryotic organisms began to absorb carbon dioxide from seawater.

C. Some prokaryotic organisms began to release oxygen into seawater.

D. Some eukaryotic organisms began to release oxygen into seawater.




Three cell types are shown in the micrographs.

[Source: left: UCSF School of Medicine, Courtesy of Prof. D Schmucker. middle: Professor Roger Meicenheimer, Miami University, Department of Botany. right: Courtesy of visualhistology.com.]

 

What feature distinguishes striated muscle fibres from the three cell types shown in the images?

A. Mitochondria

B. Nucleoid regions

C. Multinucleate structure

D. Membrane-bound organelles




The images show samples of red blood cells that were placed in different concentrations of salt solutions.

Which process explains the observations shown in the images?

A. Active transport

B. Exocytosis

C. Facilitated diffusion

D. Osmosis




The giant marine alga Halicystis ovalis is able to move sodium ions from vacuoles to the surrounding seawater through active transport.  Which condition or feature is required for this mode of transport?

A. Movement from a region of higher sodium concentration to a region of lower sodium concentration
B. A partially permeable surface
C. Membrane fluidity
D. Transmembrane proteins




Which is an essential feature of the Davson–Danielli model of membrane structure?

A. A phospholipid monolayer with intrinsic and extrinsic proteins

B. A layer of protein sandwiched between two layers of lipid

C. A phospholipid bilayer with intrinsic and extrinsic proteins

D. A layer of lipid sandwiched between two layers of protein




The diagram shows a stage in cell division.

[Source: © International Baccalaureate Organization 2019]

 

What is the stage shown?

A. Anaphase I of mitosis

B. Anaphase II of mitosis

C. Anaphase I of meiosis

D. Anaphase II of meiosis

 




Which evidence falsifies the Davson–Danielli model?

I. The presence of globular proteins within the phospholipid bilayer

II. Non-polar amino acids cause proteins to remain embedded in membranes

III. Membrane proteins remain in a fixed position inside a membrane

A. I only

B. I and II only

C. II and III only

D. I, II and III




The images show samples of red blood cells that were placed in different concentrations of salt solutions.

Which solution has the highest salt concentration?

A. The original solution

B. Solution 1

C. Solution 2

D. Solution 3




Red blood cells from a small mammal were immersed in NaCl (sodium chloride) solutions of different concentrations for 2 hours. The graph shows the percentage of hemolysed (ruptured) red blood cells at each concentration.

[Source: Zaidan, T. , de Matos, W. , Machado, É. , Junqueira, T. , Vicentini, S. , Presta, G. and Santos-Filho, S. (2010)
Cellular effects of an aqueous solution of Losartan® on the survival of Escherichia coli AB1157 in the presence
and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte. Advances
in
 Bioscience and Biotechnology, 1, 300–304. doi: 10.4236/abb.2010.14039. Available at https://www.scirp.org/pdf/ABB20100400005_18844979.pdf Licensed under a Creative
Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).]

 

What can be deduced from the graph?

A. At Y, the net movement of Na ions between red blood cells and the NaCl solutions is zero.

B. At X, Na and Cl ions disrupt the structure of cell membranes.

C. At Y, the hypertonic NaCl solutions diffuse into the red blood cells.

D. At X, water has moved by osmosis into the red blood cells.




How are villi, alveoli and nephrons similar?

A.  They are internal organs.

B.  They provide large surface areas for molecular exchange.

C.  They secrete hormones.

D.  They have a role in excretion.




Which method provides biochemical evidence that cells have begun to differentiate?

A.  Observation with a light microscope

B.  Observation with an electron microscope

C.  Examination of the DNA sequence

D.  Analysis of the proteins




Which type of transportation happens in the sodium–potassium pump?

A. Facilitated diffusion

B. Osmosis

C. Simple diffusion

D. Active transport




Stargardt’s disease, a genetic disorder that causes vision loss, is being treated using retinal cells derived from human embryonic stem cells. Why are embryonic stem cells used?

A. They are already specialized for this function.

B. They are able to differentiate into the required cell type.

C. They retain stem cell properties after specialization.

D. There are no ethical issues concerning their use.




[Source: Adapted from www.biology-resources.com. Copyright 2004–2017 D G Mackean & Ian Mackean. All rights reserved.]

The salt concentration inside the Paramecium is 1.8 %. The salt concentration in the surrounding medium suddenly drops to 0.2 %. What will be the likely response?

A. The cell will lose salt to the medium.

B. The contractile vacuole will expel more water.

C. The cell will swell and eventually burst.

D. The membrane will become more permeable to salt.




Which feature(s) allow(s) transport of glucose in blood plasma?

I. It is hydrophobic.

II. It is polar.

III. Its solubility is low at 37 °C.

A. I only

B. II only

C. I and II only

D. II and III only




What would show that a person has developed metastatic cancer?

A. Alveolus cells forming a tumour in the lungs

B. Cancer cells producing the skin pigment melanin in the liver

C. A tumour in the prostate gland increasing levels of prostate-specific antigen

D. Cancerous lymphocytes in blood plasma




The image shows a phagocytic white blood cell as seen with a transmission electron microscope.

[Source: http://www.wikidoc.org/index.php/File:Monocyte_TEM_0002.jpg, by Cafer Zorkun is licensed
under the Creative Commons Attribution/Share-Alike License]

 

Which features can be found both within this cell and in a photosynthetic bacterium?

A. Chloroplasts

B. Multiple nuclei

C. 70S ribosomes

D. Lysosomes




The diagram shows the concentration of four cyclins during the cell cycle. Which curve represents the cyclin that promotes the assembly of the mitotic spindle?




Chlorella and Paramecium are both unicellular eukaryotic organisms living in freshwater. Chlorella is photosynthetic and has a cell wall. Which organelle will be found in Paramecium but not in Chlorella?

A. Chloroplast

B. Contractile vacuole

C. Rough endoplasmic reticulum

D. Mitochondrion




When does DNA replication occur?

A. S phase of interphase

B. Early prophase

C. G phase of interphase

D. Late prophase




In which stage of the cell cycle are chromosomes duplicated?

[Source: M1llx, 2019. Cell cycle simple pl. [online] Available at: https://commons.wikimedia.org/wiki/File:Cell_cycle_simple_pl.png This file is licensed
under the Creative Commons Attribution-Share Alike 4.0 International license.
https://creativecommons.org/licenses/by-sa/4.0/deed.en [Accessed 1 August 2019].]

 

A. G1 phase

B. G2 phase

C. S phase

D. Mitosis




Two cells have the following characteristics.

Which deduction is supported by this information?

A. Both cells are from plants.

B. Cell I is more complex than cell II.

C. Cell II is an animal cell.

D. Cell I is prokaryotic.




The image shows an electron micrograph of pancreatic exocrine cells.

What is the role of the vesicles shown in the micrograph?

A. To transport hormones between the rough endoplasmic reticulum and the Golgi apparatus

B. To store glycogen when blood glucose levels are high

C. To move enzymes out of the cell by exocytosis

D. To digest cellulose




The image shows an electron micrograph of a fungus, Candida albicans.

Which terms identify the structures labelled I and II in the image?




[Source: Adapted from www.biology-resources.com. Copyright 2004–2017 D G Mackean & Ian Mackean. All rights reserved.]

Which function is accomplished by structures X and Y in the Paramecium?




The image shows an electron micrograph of virus particles known to infect the bacterium Vibrio parahaemolyticus, which is associated with gastroenteritis, wound infections and septicemia in humans and animals.

[Source: Lin, Y. and Lin, C., 2012. Transmission electron micrograph of phage ϕpp2 particles with several structural proteins. [micrograph] (BMC Genomics, 13:224).]

 

What does a virus have in common with a living cell?

A. 70S ribosomes

B. Genetic material

C. Reproduction by binary fission

D. Anaerobic respiration